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Autoimmune hepatitis, formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Common initial symptoms include fatigue or muscle aches or signs of acute liver inflammation including fever, jaundice, and right upper quadrant abdominal pain. Individuals with autoimmune hepatitis often have no initial symptoms and the disease is detected by abnormal liver function tests. Anomalous presentation of human leukocyte antigen (HLA) class II on the surface of liver cells, possibly due to genetic predisposition or acute liver infection, causes a cell-mediated immune response against the body's own liver, resulting in autoimmune hepatitis. This abnormal immune response results in inflammation of the liver, which can lead to further symptoms and complications such as fatigue and cirrhosis.〔,〕 The disease may occur in any ethnic group and at any age, but is most often diagnosed in patients between age 40 and 50. ==Classification== Four subtypes are recognised, but the clinical utility of distinguishing subtypes is limited. # positive ANA and SMA, elevated immunoglobulin G (classic form, responds well to low dose steroids); # positive LKM-1 (typically female children and teenagers; disease can be severe), LKM-2 or LKM-3; # positive antibodies against soluble liver antigen〔(【引用サイトリンク】title=autoimmune hepatitis )〕 (this group behaves like group 1) (anti-SLA, anti-LP) # no autoantibodies detected (~20%) (of debatable validity/importance) 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「autoimmune hepatitis」の詳細全文を読む スポンサード リンク
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